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Best AQUARIUM BACTERIAL ADDITIVES

At Aquarium Accessories Reviews, we take pride in our rigorous review process. Each product is handpicked based on market research, personally tested by our experienced team for functionality and durability, and evaluated for value for money. Alongside our hands-on experience, we also consider real user feedback. This meticulous approach ensures we provide honest, transparent, and comprehensive reviews to guide your aquarium accessory purchases.

We will continue to update this buyer's guide once a month or two.

The best AQUARIUM BACTERIAL ADDITIVES in 2024 - Detailed Product Descriptions

1. Seachem Equilibrium 300gram

By Seachem Store

Seachem Equilibrium 300gram

MINERALS: Equilibrium is specifically designed to establish the optimal mineral content for the planted aquarium. When this mixture is added to the aquarium it will impart a slight haze that should clear within 15–30 minutes.
EQUILIBRIUM: Does not contain sodium or chloride (which can be detrimental to a planted aquarium at elevated levels).
SUITED FOR: Equilibrium is preferably suited for use with RO (reverse osmosis) and DI (deionized) water or any mineral deficient water.
BALANCE: Equilibrium raises the essential mineral/electrolyte content (General Hardness) of the water to balance with and promote stability of the carbonate hardness.
DIRECTIONS: To raise mineral content/general hardness (GH) by 1 meq/L (3 dH), add 16 g (1 tablespoon) for every 80 L (20 US gallons) when setting up an aquarium or when making water changes (add to new water). It is normal for this product not to dissolve right away and it will not harm the tank. It will dissolve over the course of about 12 hours.

2. API MELAFIX Freshwater Fish Bacterial Infection Remedy 4-Ounce Bottle

By API Store

API MELAFIX Freshwater Fish Bacterial Infection Remedy 4-Ounce Bottle

Contains one (1) API MELAFIX Freshwater Fish Bacterial Infection Remedy 4-Ounce Bottle
Heals bacterial infections and repairs damaged fins, ulcers and open wounds
Contains natural, botanical tea tree extract to quickly and rapidly help fish
Helps treat newly-introduced fish to reduce risk of disease outbreak in freshwater aquariums
Use daily for a week when treating infections and for 3 days as a preventive when adding new fish

3. GarlicGuard, 100 mL / 3.4 fl. oz.

By Seachem Store

GarlicGuard, 100 mL / 3.4 fl. oz.

Contains 1- 100ml bottle
Garlic additive and Flavor Enhancer for freshwater and Saltwater: reef and Plant safe
All natural garlic scented odor and Flavor Enhancer for freshwater and Saltwater Fish

4. ECOLOGICAL LABS MicrobeLift Special Blend (4 oz)

By MICROBE-LIFT Store

ECOLOGICAL LABS MicrobeLift Special Blend (4 oz)

UNIQUE BLEND: Based on the blends used to clean lakes and rivers; Special Blend is a formulated mixture that creates a stable biological system in freshwater and saltwater tanks
REDUCE MAINTENANCE FREQUENCY: Special Blend breaks down hard-to-degrade substances that create sludge and decrease water quality
FISH HEALTH BENEFITS: Special Blend aquarium conditioner creates a healthy environment for any fish; along with a natural boost to improve coloring; fish will digest more food; creating less food waste; reduced ammonia levels create cleaner water
SAFE FOR USE IN A REEF TANK: Special Blend is safe for all fish invertebrates and plants in fresh brackish and salt water; You will see better coloring and polyp extension from your corals when used regularly
WORKS GREAT IN PLANTED TANKS: In addition to its cleaning ability; Special Blend increases carbon cycles and nutrient uptake in plants resulting in better growth

5. Fluval Biological Enhancer for Aquariums, 4-Ounce

By Fluval Store

Fluval Biological Enhancer for Aquariums, 4-Ounce

Immediately establishes safe biological aquarium environment
Powerful responsive ammonia and nitrite elimination
Prevents fish loss
Allows immediate introduction of fish
For Fresh and Saltwater Use

6. API Aquarium Start UP Pack Water Conditioner 1.25-Ounce Bottle 2-Pack

By API Store

API Aquarium Start UP Pack Water Conditioner 1.25-Ounce Bottle 2-Pack

Contains one (1) API AQUARIUM START UP PACK Water Conditioner 1.25-Ounce Bottle 2-Pack
Makes tap water safe for fish and reduces fish stress.
Starts aquarium cycle and allows instant addition of fish.
Comes with two API products, STRESS COAT and QUICK START, for a healthy start-up aquarium.
Use when starting a new aquarium, changing water, or adding fish. Add STRESS COAT first and then QUICK START.

7. Fritz Aquatics 75016 FritzZyme Monster 360 Concentrated Biological Conditioner for Fresh Water Aquariums, 16-Ounce

By Fritz Aquatics Store

Fritz Aquatics 75016 FritzZyme Monster 360 Concentrated Biological Conditioner for Fresh Water Aquariums, 16-Ounce

Concentrated Biological Aquarium Cleaner for Fresh Water
Promotes a Clean, Clear and Healthy Aquarium
Eliminates Foul Odors and Improves Water Clarity
Bacteria Rapidly Digest Waste
Reduces and Simplifies Maintenance

8. Api Quick Start

By API Store

Api Quick Start

Contains 2 API QUICK START Freshwater and Saltwater Aquarium Nitrifying Bacteria 16-Ounce Bottle
Allows instant addition of fish when starting a new aquarium
Reduces compounds harmful to fish when used routinely
Helps prevent fish loss in freshwater and saltwater aquariums
Pack of 2

9. Python Multi-Purpose Bio-Support Jump Start Aquarium Filter, 4 oz

By Brand: Python

Python Multi-Purpose Bio-Support Jump Start Aquarium Filter, 4 oz

Jump-starts aquarium filters with live beneficial bacteria
Designed for use with freshwater and marine aquariums
Made safe for use with fish, invertebrates, and plants
4 fl oz of solution treats 240 U.S. gal of aquarium water
Part 2 of the Python three step water treatment system

10. API STRESS COAT Aquarium Water Conditioner & API STRESS ZYME Aquarium Cleaning Solution 2x8-Ounce Bundle Pack

By API Store

API STRESS COAT Aquarium Water Conditioner & API STRESS ZYME Aquarium Cleaning Solution 2x8-Ounce Bundle Pack

Contains one (1) set of one (1) API STRESS COAT 8-Ounce Bottle and one (1) API STRESS ZYME 8-Ounce Bottle
API STRESS COAT makes tap water safe by removing chemicals from tap water that are harmful to fish, and replaces fish’s protective coat damaged by handling, shipping or fish fighting with healing power of Aloe Vera extract
Use API STRESS COAT when adding or changing water, when adding new fish and when fish are sick or injured
API STRESS ZYME adds beneficial bacteria that consumes sludge to help keep aquariums, gravel and decorations clean and to reduce maintenance
Use API STRESS ZYME weekly to maintain a clean, healthy aquarium

11. GlasGarten Bacter AE Micro Powder Water Additive for Shrimp Tanks CRS Bee Cherry (35g)

By Brand: GlasGarten

GlasGarten Bacter AE Micro Powder Water Additive for Shrimp Tanks CRS Bee Cherry (35g)

Healthy Additive For Freshwater Shrimp: Ideal For Dwarf / Nano Aquarium Shrimp And More (Neocaridina, Amano, Red Cherry, Rili, Ghost, Bamboo Shrimp, Etc)
Biofilm Development: Produces Biofilm And Essential Bacteria For Shrimp Tanks
Robust Breeding Tanks: Greatly Improves The Survival Rate Of Newborn Baby Shrimp
Trusted Product: Used At Alpha Pro Breeders Shrimp Breeding Facility, As Well As All Of The Shrimp Holding Tanks At Aquatic Arts.

12. Aqueon Pure Bacteria Supplement - 4 Pack (10 Gallon)

By Aqueon Store

Aqueon Pure Bacteria Supplement - 4 Pack (10 Gallon)

Add one PURE per 10 gallons of tank water each week.
Add two PURE per 10 gallons of tank water when starting a new aquarium
Easy to dose gel ball
Live beneficial bacteria that breaks down harmful waste
Cannot be overdosed
Helps maintain clear water
Safe for all freshwater aquariums

13. Fluval Clarify Bio for Aquarium Water Treatment, 4-Ounce Biological Cleaner for Aquariums, 8.4-Ounce

By Fluval Store

Fluval Clarify Bio for Aquarium Water Treatment, 4-Ounce Biological Cleaner for Aquariums, 8.4-Ounce

Clears organic debris
Controls new tank syndrome
Reduces aquarium maintenance by cleaning gravel, power filters, decorations and interior surfaces
Rapidly reduces organic waste

14. Fluval Water Treatment for Aquariums Bundle, Biological Enhancer and Water Conditioner

By Fluval Store

Fluval Water Treatment for Aquariums Bundle, Biological Enhancer and Water Conditioner

Biological Enhancer infused with a powerful team of beneficial bacteria that immediately inoculates aquarium water
Biological enhancer eliminates ammonia and nitrite
Water conditioner makes tap water safe for fish by neutralizing chlorine, chloramines and heavy metals
Water treatments are suitable for use in both freshwater and saltwater aquariums
Includes one 16.9 oz. bottle of Fluval Biological Enhancer and one 8.4 oz. bottle of Fluval Water Conditioner

15. Aqueon Pure Betta Beads, Purple

By Aqueon Store

Aqueon Pure Betta Beads, Purple

Provides live beneficial bacteria and enzymes to maintain clear water
Great environmental enrichment activity for Bettas! Watch as they play in and out of the soft gravel like a fun ball pit
Soft biodegradable gravel encourages the natural foraging behavior of bettas for mental stimulation
Aids in maintaining a healthy aquarium by breaking down organic sludge for a healthy balanced environment
For use in unfiltered betta habitats. Add 1 pouch of betta beads per 1 gallon of water
For best results replace betta beads once a month (add 1 pouch per 1 gallon of water) and perform a 25% water change every 2 weeks
If betta beads shrink prematurely, this is a quick indicator that the water hardness is not optimal for your betta - we recommend changing the water with soft (deionized or specially filtered) betta waters

16. Fluval Plant and Shrimp Stratum, for Fish Tanks, 8.8 lbs. & API Quick Start Freshwater and Saltwater Aquarium Nitrifying Bacteria 16-Ounce Bottle

By Fluval Store

Fluval Plant and Shrimp Stratum, for Fish Tanks, 8.8 lbs. & API Quick Start Freshwater and Saltwater Aquarium Nitrifying Bacteria 16-Ounce Bottle

Product 1: Fluval Stratum is made of mineral rich volcanic soil
Product 1: Stimulates strong aquarium plant growth
Product 1: Promotes neutral to mildly acidic pH
Product 1: Suitable for live plants or shrimp
Product 2: Contains one (1) API QUICK START Freshwater and Saltwater Aquarium Nitrifying Bacteria 16-Ounce Bottle
Product 2: Allows instant addition of fish when starting a new aquarium
Product 2: Reduces compounds harmful to fish when used routinely
Product 2: Helps prevent fish loss in freshwater and saltwater aquariums

17. API Quick Start Freshwater and Saltwater Aquarium Nitrifying Bacteria 16-Ounce Bottle & Stress Coat Aquarium Water Conditioner 16-Ounce Bottle

By API Store

API Quick Start Freshwater and Saltwater Aquarium Nitrifying Bacteria 16-Ounce Bottle & Stress Coat Aquarium Water Conditioner 16-Ounce Bottle

Product 1: Contains one (1) API QUICK START Freshwater and Saltwater Aquarium Nitrifying Bacteria 16-Ounce Bottle
Product 1: Allows instant addition of fish when starting a new aquarium
Product 1: Reduces compounds harmful to fish when used routinely
Product 1: Helps prevent fish loss in freshwater and saltwater aquariums
Product 2: Contains one (1) API STRESS COAT Aquarium Water Conditioner 16-Ounce Bottle
Product 2: Makes tap water safe and protects fish with dual-action formula
Product 2: Removes chemicals from tap water that are harmful to fish
Product 2: Replaces fish’s protective coat damaged by handling, shipping or fish fighting with healing power of Aloe Vera extract

18. API Quick Start Freshwater and Saltwater Aquarium Nitrifying Bacteria 16-Ounce Bottle & ACCU-Clear Freshwater Aquarium Water Clarifier 8-Ounce Bottle

By API Store

API Quick Start Freshwater and Saltwater Aquarium Nitrifying Bacteria 16-Ounce Bottle & ACCU-Clear Freshwater Aquarium Water Clarifier 8-Ounce Bottle

Product 1: Contains one (1) API QUICK START Freshwater and Saltwater Aquarium Nitrifying Bacteria 16-Ounce Bottle
Product 1: Allows instant addition of fish when starting a new aquarium
Product 1: Reduces compounds harmful to fish when used routinely
Product 1: Helps prevent fish loss in freshwater and saltwater aquariums
Product 2: Contains one (1) API ACCU-CLEAR Freshwater Aquarium Water Clarifier 8-Ounce Bottle
Product 2: Clears cloudy aquarium water
Product 2: Clumps floating particles into large clusters that can be easily removed by an aquarium filter
Product 2: Works fast and maximizes filter efficiency

19. API ACCU-Clear Freshwater Aquarium Water Clarifier 8-Ounce Bottle & Stress Coat Aquarium Water Conditioner 16-Ounce Bottle

By API Store

API ACCU-Clear Freshwater Aquarium Water Clarifier 8-Ounce Bottle & Stress Coat Aquarium Water Conditioner 16-Ounce Bottle

Product 1: Contains one (1) API ACCU-CLEAR Freshwater Aquarium Water Clarifier 8-Ounce Bottle
Product 1: Clears cloudy aquarium water
Product 1: Clumps floating particles into large clusters that can be easily removed by an aquarium filter
Product 1: Works fast and maximizes filter efficiency
Product 2: Contains one (1) API STRESS COAT Aquarium Water Conditioner 16-Ounce Bottle
Product 2: Makes tap water safe and protects fish with dual-action formula
Product 2: Removes chemicals from tap water that are harmful to fish
Product 2: Replaces fish’s protective coat damaged by handling, shipping or fish fighting with healing power of Aloe Vera extract

20. API Stress Zyme Freshwater and Saltwater Aquarium Cleaning Solution 16-Ounce Bottle & Quick Start Freshwater and Saltwater Aquarium Nitrifying Bacteria 16-Ounce Bottle

By API Store

API Stress Zyme Freshwater and Saltwater Aquarium Cleaning Solution 16-Ounce Bottle & Quick Start Freshwater and Saltwater Aquarium Nitrifying Bacteria 16-Ounce Bottle

Product 1: Contains one (1) API STRESS ZYME Freshwater and Saltwater Aquarium Cleaning Solution 16-Ounce Bottle
Product 1: Keeps freshwater and saltwater aquariums clean and reduces maintenance
Product 1: Consumes sludge to help keep gravel and decorations clean
Product 1: Adds beneficial bacteria for a healthy aquarium
Product 2: Contains one (1) API QUICK START Freshwater and Saltwater Aquarium Nitrifying Bacteria 16-Ounce Bottle
Product 2: Allows instant addition of fish when starting a new aquarium
Product 2: Reduces compounds harmful to fish when used routinely
Product 2: Helps prevent fish loss in freshwater and saltwater aquariums

21. API Aqua Essential Water Conditioner 16 Ounce Bottle & ACCU-Clear Freshwater Aquarium Water Clarifier 8-Ounce Bottle

By API Store

API Aqua Essential Water Conditioner 16 Ounce Bottle & ACCU-Clear Freshwater Aquarium Water Clarifier 8-Ounce Bottle

Product 1: Contains one (1) API AQUA ESSENTIAL Water Conditioner 16 ounce bottle; treats up to 4,730 U.S. Gallons
Product 1: WORKS INSTANTLY: Highly concentrated aquarium treatment works instantly to remove harmful chemicals, making tap water safe for fish in freshwater, saltwater and planted aquariums; Reduces the risk of fish loss when starting or maintaining a fish tank
Product 1: DECHLORINATOR: Removes chlorine, chloramines, heavy metals which are found in tap water and can cause gill and tissue damage, breathing difficulty, stress and fish death
Product 1: AMMONIA REMOVER: Removes the toxic ammonia continually released by fish through their gills, urine and solid waste. Uneaten food and decaying organic matter also add ammonia. Small amounts of ammonia stress fish; large amounts of ammonia will kill fish
Product 2: Contains one (1) API ACCU-CLEAR Freshwater Aquarium Water Clarifier 8-Ounce Bottle
Product 2: Clears cloudy aquarium water
Product 2: Clumps floating particles into large clusters that can be easily removed by an aquarium filter
Product 2: Works fast and maximizes filter efficiency

22. API Liquid Super ICK Cure Freshwater and Saltwater Fish Medication 16-Ounce Bottle & ACCU-Clear Freshwater Aquarium Water Clarifier 8-Ounce Bottle

By API Store

API Liquid Super ICK Cure Freshwater and Saltwater Fish Medication 16-Ounce Bottle & ACCU-Clear Freshwater Aquarium Water Clarifier 8-Ounce Bottle

Product 1: Contains one (1) API LIQUID SUPER ICK CURE Freshwater and Saltwater Fish Medication 16-Ounce Bottle
Product 1: Treats "ich" white spot disease in fish and secondary bacterial fish infections
Product 1: Quickly kills ich parasite, typically within 24 hours of first dose
Product 1: Corals and invertebrates may be sensitive to this medication. We do not recommend usage in reef aquariums or any freshwater or saltwater aquarium with invertebrates.
Product 2: Contains one (1) API ACCU-CLEAR Freshwater Aquarium Water Clarifier 8-Ounce Bottle
Product 2: Clears cloudy aquarium water
Product 2: Clumps floating particles into large clusters that can be easily removed by an aquarium filter
Product 2: Works fast and maximizes filter efficiency

23. API Quick Start Freshwater and Saltwater Aquarium Nitrifying Bacteria 32-Ounce Bottle & Stress Coat Aquarium Water Conditioner 16-Ounce Bottle

By API Store

API Quick Start Freshwater and Saltwater Aquarium Nitrifying Bacteria 32-Ounce Bottle & Stress Coat Aquarium Water Conditioner 16-Ounce Bottle

Product 1: Contains one (1) API QUICK START Freshwater and Saltwater Aquarium Nitrifying Bacteria 32-Ounce Bottle
Product 1: Allows instant addition of fish when starting a new aquarium
Product 1: Reduces compounds harmful to fish when used routinely
Product 1: Helps prevent fish loss in freshwater and saltwater aquariums
Product 2: Contains one (1) API STRESS COAT Aquarium Water Conditioner 16-Ounce Bottle
Product 2: Makes tap water safe and protects fish with dual-action formula
Product 2: Removes chemicals from tap water that are harmful to fish
Product 2: Replaces fish’s protective coat damaged by handling or fish fighting with healing power of Aloe Vera extract

24. API Quick Start Freshwater and Saltwater Aquarium Nitrifying Bacteria 32-Ounce Bottle & ACCU-Clear Freshwater Aquarium Water Clarifier 8-Ounce Bottle

By API Store

API Quick Start Freshwater and Saltwater Aquarium Nitrifying Bacteria 32-Ounce Bottle & ACCU-Clear Freshwater Aquarium Water Clarifier 8-Ounce Bottle

Product 1: Contains one (1) API QUICK START Freshwater and Saltwater Aquarium Nitrifying Bacteria 32-Ounce Bottle
Product 1: Allows instant addition of fish when starting a new aquarium
Product 1: Reduces compounds harmful to fish when used routinely
Product 1: Helps prevent fish loss in freshwater and saltwater aquariums
Product 2: Contains one (1) API ACCU-CLEAR Freshwater Aquarium Water Clarifier 8-Ounce Bottle
Product 2: Clears cloudy aquarium water
Product 2: Clumps floating particles into large clusters that can be easily removed by an aquarium filter
Product 2: Works fast and maximizes filter efficiency

25. API Quick Start Freshwater and Saltwater Aquarium Nitrifying Bacteria 16-Ounce Bottle & Ammo-Lock Freshwater and Saltwater Aquarium Ammonia Detoxifier 16-Ounce Bottle

By API Store

API Quick Start Freshwater and Saltwater Aquarium Nitrifying Bacteria 16-Ounce Bottle & Ammo-Lock Freshwater and Saltwater Aquarium Ammonia Detoxifier 16-Ounce Bottle

Product 1: Contains one (1) API QUICK START Freshwater and Saltwater Aquarium Nitrifying Bacteria 16-Ounce Bottle
Product 1: Allows instant addition of fish when starting a new aquarium
Product 1: Reduces compounds harmful to fish when used routinely
Product 1: Helps prevent fish loss in freshwater and saltwater aquariums
Product 2: Contains one (1) API AMMO-LOCK Freshwater and Saltwater Aquarium Ammonia Detoxifier 16-Ounce Bottle
Product 2: Detoxifies ammonia in aquarium water and tap water
Product 2: Works instantly to make aquarium water safe for fish
Product 2: Reduction in ammonia levels measurable on any API Test Kits

26. API Leaf Zone Freshwater Aquarium Plant Fertilizer 18-Ounce Bottle White & Quick Start Freshwater and Saltwater Aquarium Nitrifying Bacteria 16-Ounce Bottle

By API Store

API Leaf Zone Freshwater Aquarium Plant Fertilizer 18-Ounce Bottle White & Quick Start Freshwater and Saltwater Aquarium Nitrifying Bacteria 16-Ounce Bottle

Product 1: Aquarium plant food
Product 1: Promotes healthy aquarium plants
Product 1: For freshwater tanks
Product 1: Item Package weight : 1.25 pounds
Product 2: Contains one (1) API QUICK START Freshwater and Saltwater Aquarium Nitrifying Bacteria 16-Ounce Bottle
Product 2: Allows instant addition of fish when starting a new aquarium
Product 2: Reduces compounds harmful to fish when used routinely
Product 2: Helps prevent fish loss in freshwater and saltwater aquariums

author img Lucas Carter

Our Editor-in-Chief, Lucas Carter, brings over twenty years of hands-on experience in the world of aquaristics. He is not just an expert in aquarium keeping but also a passionate advocate for the hobby. Lucas's extensive knowledge of aquarium accessories, understanding of different aquatic ecosystems, and a keen eye for product quality set the standard for our reviews. His personal commitment is to guide both novice and experienced aquarium enthusiasts through the vast ocean of products, helping them create the ideal environment for their aquatic friends.